对乙酰氨基酚|感冒病人同时吃2种药导致肝衰竭,进了医院ICU!为了家人快看看( 三 )


最后也提醒大家 , 在感冒药选用时一定要看清楚说明书上的成分表和剂量 。市面上销售的感冒药很多是复方制剂 , 包括中成药维C银翘片等 , 这些药都含有对乙酰氨基酚 。
如果你已经买了一种复方感冒药 , 就别再叠加服用其他复方成分的药了 , 不然很可能导致药物过量中毒 。
【对乙酰氨基酚|感冒病人同时吃2种药导致肝衰竭,进了医院ICU!为了家人快看看】希望楼主的好友治疗顺利 , 也希望这个案例能唤起大家的警醒 , 为了您和家人的健康 , 加强安全用药意识 。
参考文献
[1]Department of Health and Human Services, Food and Drug Administration. Internal analgesic, antipyretic, and antirheumatic drug products for over-the-counter human use; proposed amendment of the tentative final monograph; required warnings and other labeling [OL]. Fed Regist 2006; 71:77314–52.
[2]https://apps.who.int/medicinedocs/en/d/Jh2929e/6.2.html
[3]Hayward K L, Powell E E, Irvine K M, et al. Can paracetamol (acetaminophen) be administered to patients with liver impairment?[J]. British journal of clinical pharmacology, 2016, 81(2): 210-222.
[4]Bower WA, Johns M, Margolis HS, Williams IT, Bell BP. Population-based surveillance for acute liver failure. Am J Gastroenterol. 2007;102:2459-63.
[5]Yan M, Huo Y, Yin S, et al. Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions[J]. Redox biology, 2018, 17: 274-283.
[6]Lee WM. Acetaminophen and the U.S. acute liver failure Study group: lowering the risks of hepatic failure. Hepatology. 2004;40(1):6–9.
[7]https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-prescription-acetaminophen-products-be-limited-325-mg-dosage-unit
[8] Aitken P, Stanescu I, Playne R, et al. An integrated safety analysis of combined acetaminophen and ibuprofen (Maxigesic/Combogesic) in adults[J]. Journal of pain research, 2019, 12: 621.
[9] 中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].中华肝脏病杂志,2015,23(11):810-820.
[10] Rumack B, Heard K, Green J, et al. Effect of therapeutic doses of acetaminophen (up to 4 g/day) on serum alanine aminotransferase levels in subjects consuming ethanol: systematic review and meta‐analysis of randomized controlled trials[J]. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2012, 32(9): 784-791.
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